Analysis of mid-trimester maternal serum β-hCG and AFP as markers of preterm and term adverse pregnancy outcomes form a tertiary care hospital, Morang, Nepal

Background: Mid-trimester maternal serum markers have been used for prenatal aneuploidy screening a long time. The aim of the study was to assess mid-term levels β-human chorionic gonadotropin and alpha-fetoproteins placenta-mediated adverse pregnancy outcomes (PMAPOs) in preterm term pregnancies.
 Material methods: A prospective cohort involving nulliparous women with singletons without or fatal fetal abnormalities carried out tertiary care hospital, Morang, Nepal. AFP β-hCG were estimated between 13 17 weeks gestation mother's serum. All values multiples median (MoM) compared PMAPOs.
 Results: obtained 176 300 women. MoM (1.3 vs 1.1) (1.4 higher PMAPOs-affected than controls.
 Conclusion:Preterm PMAPOs, but not are more likely present when β -hCG significant 2.0 MoM. If growth is within normal range at 37 gestation, it advisable that increased receive regular care.